Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding.
نویسندگان
چکیده
Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 77 شماره
صفحات -
تاریخ انتشار 2012